PL 017
1 Image
Description: Selective μ agonist
Biological Activity
Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.Technical Data
M.Wt:
535.64
Formula:
C29H37N5O5
Sequence:
YPFP
(Modifications:Phe-3 = N-methyl-Phe, Pro-4 = D-Pro & C-terminal amide)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
83397-56-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Potent morphiceptin analogs: structure activity relationships and morphine-like activities.
Chang et al.
J.Pharmacol.Exp.Ther., 1983;227:403 -
Behavioral effects of the μ-opioid peptide agonists DAMGO, DALDA and PL017 on locomotor activities.
Meyer and Meyer
Pharmacol.Biochem.Behav., 1993;46:391 -
Body temperature and analgesic effects of selective mu and kappa opioid receptor agonists microdialyzed into rat brain.
Xin et al.
J.Pharmacol.Exp.Ther., 1997;281:499
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