Catalog Number: 2567
Alternate Names: Proteolipid protein (139-151)
Biological Activity
Synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.
Technical Data
  • M.Wt:
    1521.74
  • Formula:
    C72H104N20O17
  • Sequence:
    HSLGKWLGHPDKF
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    122018-58-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein.
    Sobel et al.
    J.Neuropathol.Exp.Neurol., 1990;49:468
  2. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides.
    Kuchroo et al.
    Pathobiology., 1991;59:305
  3. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.
    Tuohy et al.
    J.Immunol., 1989;142:1523
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PLP (139-151) include:

3 Citations: Showing 1 - 3
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  1. A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model.
    Authors: Arima Et al.
    Elife 2015;4
  2. Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis.
    Authors: Mondal Et al.
    J Clin Cell Immunol 2012;3:124
  3. Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.
    Authors: Jana Et al.
    J Biol Chem 2012;287:34134

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