PLpro inhibitor 6

Key Product Details

Product Description

PLpro inhibitor 6 is a SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC₅₀ values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC₅₀ values are 13.1 and 21 μM, respectively).

Product Specifications for PLpro inhibitor 6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PLpro inhibitor 6

The following data is based on the product molecular weight 346.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.43 mL	28.87 mL
5 mM	0.58 mL	2.89 mL	5.77 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ratia A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18852458
• Freitas Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect.Dis. 2020 PMID: 32428392

Product Documents for PLpro inhibitor 6