PLpro inhibitor 6
Chemical Name: 5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
Biological ActivityPLpro inhibitor 6 is a SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC50 values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 μM, respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.
Ratia et al.
Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-Like protease.
Freitas et al.
ACS Infect.Dis., 2020;
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