(+)-Anabasine hydrochloride

Key Product Details

Product Description

(+)-Anabasine hydrochloride is a high affinity neuronal nicotinic ACh receptor partial agonist (K_i values are 0.058, 0.26 and 7.2 μM for rat α7, rat α4β2 and fish skeletal muscle nAChRs respectively). Also stimulates Ca²⁺-dependent catecholamine release from rat adrenomedullary cells in vitro.

Product Specifications for (+)-Anabasine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (+)-Anabasine hydrochloride

The following data is based on the product molecular weight 198.69.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.03 mL	25.16 mL	50.33 mL
5 mM	1.01 mL	5.03 mL	10.07 mL
10 mM	0.50 mL	2.52 mL	5.03 mL
50 mM	0.10 mL	0.50 mL	1.01 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

• Hong Effect of anabasine on catecholamine secreation from the perfused rat adrenal medulla. J.Cardiol. 2007 PMID: 18186309
• Parker Neuronal nicotinic receptor β2 and β4 subunits confer large differences in agonist binding affinity. Mol.Pharmacol. 1998 PMID: 9855644
• Lu Desensitization of nicotinic agonist-induced [³H]γ-aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J.Pharmacol.Exp.Ther. 1999 PMID: 10565833
• Kem Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 1997 PMID: 9399967

Product Documents for (+)-Anabasine hydrochloride