(+)-JQ1 carboxylic acid

Tocris Bioscience | Catalog # 6588

Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
Tocris Bioscience
Discontinued Product
6588 has been discontinued. View all Degrader Building Blocks products.

Key Product Details

Description

Carboxylic acid-functionalized BET bromodomain inhibitor; target ligand for PROTACs
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Product Description

(+)-JQ1 carboxylic acid is a BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499) with a carboxylic acid functional group for conjugation reactions. Can be used as a precursor to PROTAC® Degraders that targets BET bromodomains after conjugation to a linker and E3 ligase ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for (+)-JQ1 carboxylic acid

Molecular Weight

400.88

Formula

C19H17ClN4O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid

CAS Number

202592-23-2

PubChem ID

66828107

InChI Key

LJOSBOOJFIRCSO-AWEZNQCLSA-N

SMILES

OC(C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C3=C(SC(C)=C3C)N4C1=NN=C4C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.09 100
Ethanol 40.09 100

Preparing Stock Solutions for (+)-JQ1 carboxylic acid

The following data is based on the product molecular weight 400.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.47 mL 24.95 mL
5 mM 0.50 mL 2.49 mL 4.99 mL
10 mM 0.25 mL 1.25 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for (+)-JQ1 carboxylic acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-JQ1 carboxylic acid

For research use only

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