(+)-MK 801 maleate

Tocris Bioscience | Catalog # 0924

Non-competitive NMDA antagonist; acts at ion channel site
Tocris Bioscience

Key Product Details

Description

Non-competitive NMDA antagonist; acts at ion channel site

Alternative Names

Dizocilpine
View all NMDA Receptor Antagonists »

Product Description

(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Product Specifications for (+)-MK 801 maleate

Molecular Weight

337.37

Formula

C16H15N.C4H4O4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate

CAS Number

77086-22-7

PubChem ID

6420042

InChI Key

QLTXKCWMEZIHBJ-PJGJYSAQSA-N

SMILES

O=C(O)/C=C\C(O)=O.C[C@]1(N4)C3=C(C=CC=C3)C[C@@H]4C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.37 10 with gentle warming
DMSO 33.74 100

Preparing Stock Solutions for (+)-MK 801 maleate

The following data is based on the product molecular weight 337.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.64 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.30 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 110 publications citing the usage of this product.

Product Documents for (+)-MK 801 maleate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-MK 801 maleate

For research use only

Citations for (+)-MK 801 maleate

Customer Reviews for (+)-MK 801 maleate (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used (+)-MK 801 maleate?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Product performed ideally over years and would buy again.
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Sprague-Dawley rats primary neuronal
    Verified Customer | Posted 04/04/2020
    10 μM MK-801 for 10 min
    (+)-MK 801 maleate 0924

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All