Catalog Number: 1380
Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid
Biological Activity
Highly potent and selective inhibitor of� glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a Ki value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca Ltd.
Background References
  1. Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
    Rahn et al.
    Proc.Natl.Acad.Sci.U S A (Epub ahead of print], 2012;
  2. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase.
    Jackson et al.
    J.Med.Chem., 1996;39:619
  3. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.
    Slusher et al.
    Nat.Med., 1999;5:1396
  4. NAALADase inhibition protects motor neurons against chronic glutamate toxicity.
    Thomas et al.
    Eur.J.Pharmacol., 2003;471:177
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