PMPA (NAALADase inhibitor)

Key Product Details

Product Description

PMPA (NAALADase inhibitor) is a highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α-linked dipeptidase/NAALADase) with a K_i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Product Specifications for PMPA (NAALADase inhibitor)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PMPA (NAALADase inhibitor)

The following data is based on the product molecular weight 226.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.42 mL	22.11 mL	44.22 mL
5 mM	0.88 mL	4.42 mL	8.84 mL
10 mM	0.44 mL	2.21 mL	4.42 mL
50 mM	0.09 mL	0.44 mL	0.88 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Rahn Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis. Proc.Natl.Acad.Sci.U S A (Epub ahead of print] 2012 PMID: 23169655
• Slusher Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury. Nat.Med. 1999 PMID: 10581082
• Thomas NAALADase inhibition protects motor neurons against chronic glutamate toxicity. Eur.J.Pharmacol. 2003 PMID: 12826236
• Jackson Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase. J.Med.Chem. 1996 PMID: 8558536

Product Documents for PMPA (NAALADase inhibitor)