PMX 205

   
Product Datasheet
Catalog Number:5196
Chemical Name:
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Biological Activity
Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant.
Technical Data
  • M.Wt:
    839.05
  • Formula:
    C45H62N10O6
  • Sequence:
    XPXWR

    (Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)

  • Solubility:
    Soluble to 1 mg/ml in water with sonication
  • Storage:
    Store at -20°C
  • CAS No:
    514814-49-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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