PMX 205

Catalog # Availability Size / Price Qty
5196/1
PMX 205
1 Image
Description: Potent C5a receptor peptide antagonist

Purity: ≥95%

Product Details
Citations (1)
Supplemental Products
Reviews

Biological Activity

PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

Technical Data

M.Wt:
839.05
Formula:
C45H62N10O6
Sequence:
XPXWR

(Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, X-3 = D-Cha, Lactam bridge: Orn-1 to Arg-5)

Solubility:
Soluble to 1 mg/ml in water with sonication
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
514814-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citation for PMX 205

The citations listed below are publications that use Tocris products. Selected citations for PMX 205 include:

1 Citation: Showing 1 - 1

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