Very selective, high affinity 5-HT1D
receptor agonist (Ki
values are 6 and > 18000 nM at human 5-HT1D
receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo
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Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633.
McCall et al.
Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors.
Sanchez-Lopez et al.
Bovine isolated middle cerebral artery contractions to antimigraine drugs.
Roon et al.