PNU 37883 hydrochloride

Tocris Bioscience | Catalog # 2095

Vascular Kir6 (KATP) channel blocker
Tocris Bioscience
Discontinued Product
2095 has been discontinued. View all Inward Rectifier Potassium Channel Blockers products.

Key Product Details

Description

Vascular Kir6 (KATP) channel blocker
View all Inward Rectifier Potassium Channel Blockers »

Product Description

PNU 37883 hydrochloride is a novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Product Specifications for PNU 37883 hydrochloride

Molecular Weight

381.98

Formula

C21H35N3O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride

CAS Number

57568-80-6

PubChem ID

64392

InChI Key

FZALCKUJYZCDOX-UHFFFAOYSA-N

SMILES

C1(CC3C2)CC2(/N=C(N5CCOCC5)/NC4CCCCC4)CC(C3)C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.55 25
Ethanol 38.2 100

Preparing Stock Solutions for PNU 37883 hydrochloride

The following data is based on the product molecular weight 381.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.62 mL 13.09 mL 26.18 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
10 mM 0.26 mL 1.31 mL 2.62 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for PNU 37883 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PNU 37883 hydrochloride

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for PNU 37883 hydrochloride

Customer Reviews for PNU 37883 hydrochloride (1)

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  • PNU 37883 was used to understand whether it shows BK channel blocking effect
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/31/2018
    I suggest using an alternate channel blocker to measure blocking action to identify the variation with PNU 37883.
    PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.
    PNU 37883 hydrochloride 2095

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