Catalog Number: 2095
Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Biological Activity
Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
Technical Data
  • M.Wt:
    381.98
  • Formula:
    C21H35N3O.HCl
  • Solubility:
    Soluble to 25 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    57568-80-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs.
    Humphrey and Ludens
    J.Cardiovasc.Pharmacol., 1998;31:894
  2. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
    Cui et al.
    Br.J.Pharmacol., 2003;139:122
  3. Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
    Kovalev et al.
    Br.J.Pharmacol., 2004;141:867

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