Chemical Name:N-Cyclohexyl-N'-tricyclo[126.96.36.199,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Biological Activity Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
Soluble to 25 mM in DMSO and to 100 mM in ethanol
Desiccate at RT
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