PNU 37883 hydrochloride

Catalog # Availability Size / Price Qty
2095/10
2095/50
PNU 37883 hydrochloride | CAS No. 57568-80-6 | Inward Rectifier Potassium Channel Blockers
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Description: Vascular Kir6 (KATP) channel blocker

Chemical Name: N-Cyclohexyl-N'-tricyclo[3.3.1.13,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride

Purity: ≥99%

Product Details
Reviews (1)

Biological Activity

Novel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.

Technical Data

M.Wt:
381.98
Formula:
C21H35N3O.HCl
Solubility:
Soluble to 25 mM in DMSO and to 100 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
57568-80-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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PNU 37883 was used to understand whether it shows BK channel blocking effect
By Anonymous on 10/31/2018
Species: Human

PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.


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