PNU 37883 hydrochloride
Chemical Name: N-Cyclohexyl-N'-tricyclo[22.214.171.124,7]dec-1-yl-4-morpholinecarboximidamide hydrochloride
Biological ActivityNovel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs.
Humphrey and Ludens
Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A.
Cui et al.
Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.
Kovalev et al.
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Average Rating: 4 (Based on 1 Review)
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PNU 37883 was used to understand whether it shows BK channel blocking effect. The product worked ideally although inhibition data obtained from the product shows variation.