Binds to β
= 450 nM). Inhibits the interaction between β
-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset et al.
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells and McClendon
The citations listed below are publications that use Tocris products. Selected citations for PNU 74654 include:
Showing Results 1 - 5 of 5