PNU 74654

Tocris Bioscience | Catalog # 3534

β-catenin binder; inhibits Wnt signaling
Tocris Bioscience

Key Product Details

Description

β-catenin binder; inhibits Wnt signaling
View all beta-Catenin Compounds »

Product Description

Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.

Product Specifications for PNU 74654

Molecular Weight

320.34

Formula

C19H16N2O3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide

CAS Number

113906-27-7

PubChem ID

9836739

InChI Key

JJEDWBQZCRESJL-DEDYPNTBSA-N

SMILES

O=C(N/N=C/C2=CC=C(C)O2)C1=C(OC3=CC=CC=C3)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.03 100

Preparing Stock Solutions for PNU 74654

The following data is based on the product molecular weight 320.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.12 mL 15.61 mL 31.22 mL
5 mM 0.62 mL 3.12 mL 6.24 mL
10 mM 0.31 mL 1.56 mL 3.12 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for PNU 74654

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PNU 74654

For research use only

Customer Reviews for PNU 74654 (1)

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  • Neural Induction Conditions
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: H9
    Verified Customer | Posted 03/22/2020
    2 μM PNU-74654
    PNU 74654 3534

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