Chemical Name: 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
Biological ActivityBinds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.
Trosset et al.
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Wells and McClendon
Citations for PNU 74654
The citations listed below are publications that use Tocris products. Selected citations for PNU 74654 include:
5 Citations: Showing 1 - 5
Transcription factor binding dynamics during human ES cell differentiation.
Authors: Tsankov Et al.
Stem Cells Int 2015;518:344
Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells.
Authors: Liao Et al.
Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.
Authors: Yang Et al.
Cell Reprogram 2015;2015:270428
β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion.
Authors: Corritore Et al.
Ann Neurol 2014;16:456
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
Authors: Baril Et al.
PLoS Pathog 2013;9:e1003416
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VersaClone cDNA Plasmids
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