Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Biological ActivityPNU 96415E is an antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.
Tang et al.
Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands.
Goudie et al.
Citation for PNU 96415E
The citations listed below are publications that use Tocris products. Selected citations for PNU 96415E include:
1 Citation: Showing 1 - 1
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for PNU 96415E
There are currently no reviews for this product. Be the first to review PNU 96415E and earn rewards!
Have you used PNU 96415E?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image