Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride
Biological ActivityAntipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.
Tang et al.
Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands.
Goudie et al.
Citation for PNU 96415E
The citations listed below are publications that use Tocris products. Selected citations for PNU 96415E include:
1 Citation: Showing 1 - 1
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
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