Antipsychotic agent. Displays high affinity for dopamine D4
and serotonergic 5-HT2A
receptors and relatively weak affinity at D2
values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4
and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.
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All Tocris products are intended for laboratory research use only.
PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties.
Tang et al.
Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands.
Goudie et al.