PNU 96415E

Key Product Details

Product Description

PNU 96415E is an antipsychotic agent. Displays high affinity for dopamine D₄ and serotonergic 5-HT_2A receptors and relatively weak affinity at D₂ receptors (K_i values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D₄, 5-HT_2A, 5-HT_1A, α₁, D₂, D₃, D₁, α₂ and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Product Specifications for PNU 96415E

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PNU 96415E

The following data is based on the product molecular weight 413.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.19 mL	120.96 mL	241.92 mL
0.5 mM	4.84 mL	24.19 mL	48.38 mL
1 mM	2.42 mL	12.10 mL	24.19 mL
5 mM	0.48 mL	2.42 mL	4.84 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Goudie Discriminative stimulus properties of the atypical neuroleptic cloz. in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 1998 PMID: 9890260
• Tang PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 1997 PMID: 9103528

Product Documents for PNU 96415E