Polygodial

Catalog # Availability Size / Price Qty
3197/10
3197/50
Polygodial | CAS No. 6754-20-7 | TRPA1 Activators
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Description: TRPA1 channel activator; analgesic and antifungal

Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Technical Data

M.Wt:
234.33
Formula:
C15H22O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
6754-20-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae.
    Lunde and Kubo
    Antimicrob.Agents Chemother., 2000;44:1943
  2. TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.
    Escalera et al.
    J.Biol.Chem., 2008;283:24136
  3. Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.
    Matsuda et al.
    Bioorg.Med.Chem.Letts., 2002;12:477

Product Datasheets

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Citation for Polygodial

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