Polygodial

Key Product Details

Product Description

Polygodial is a TRPA1 channel activator (EC₅₀ = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.

Product Specifications for Polygodial

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Polygodial

The following data is based on the product molecular weight 234.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.27 mL	21.34 mL	42.67 mL
5 mM	0.85 mL	4.27 mL	8.53 mL
10 mM	0.43 mL	2.13 mL	4.27 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Escalera TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 2008 PMID: 18550530
• Matsuda Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 2002 PMID: 11814823
• Lunde and Kubo Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 2000 PMID: 10858359

Product Documents for Polygodial