Chemical Name: (1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
Biological ActivityPolygodial is a TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae.
Lunde and Kubo
Antimicrob.Agents Chemother., 2000;44:1943
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.
Escalera et al.
Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.
Matsuda et al.
Citation for Polygodial
The citations listed below are publications that use Tocris products. Selected citations for Polygodial include:
1 Citation: Showing 1 - 1
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction.
Authors: Shi Et al.
Mol Cancer 2015;21:4852
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