TRPA1 channel activator (EC50
= 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.
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All Tocris products are intended for laboratory research use only.
TRPA1 mediates the noxious effects of natural sesquiterpene deterrents.
Escalera et al.
Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae.
Lunde and Kubo
Antimicrob.Agents Chemother., 2000;44:1943
Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action.
Matsuda et al.
The citations listed below are publications that use Tocris products. Selected citations for Polygodial include:
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