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POM 1

Catalog #: 2689
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2689/50
POM 1 | CAS No. 12141-67-2 | NTPDase Inhibitors
1 Image
Description: Inhibitor of E-NTPDases
Alternative Names: Sodium polyoxotungstate

Chemical Name: Sodium metatungstate

Product Details
Citations (12)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data

M.Wt:
2986.01
Formula:
H2O40Na6W12
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
12141-67-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for POM 1

The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:

12 Citations: Showing 1 - 10

  1. Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients.
    Authors: Alvarez-Sanchez Et al.
    Sci Rep  2019;9:2302
  2. Kinetics of MSC-based enzyme therapy for immunoregulation.
    Authors: Burr and Parekkadan
    J Transl Med  2019;17:263
  3. Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances.
    Authors: Ohradanova-Repic Et al.
    Front Immunol  2018;9:852
  4. Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.
    Authors: Crittenden Et al.
    Immunol Cell Biol  2018;96:1049
  5. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
    Authors: Hirata Et al.
    Cell Stem Cell  2018;22:445
  6. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.
    Authors: Del Papa Et al.
    Leukemia  2016;30:1931
  7. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep.  2016;14:1218
  8. Extracellular ATP protects endothelial cells against DNA damage.
    Authors: Aho Et al.
    Purinergic Signal  2016;12:575
  9. A dual role for autophagy in a murine model of lung cancer.
    Authors: Rao Et al.
    Cancer Biol Ther  2014;5:3056
  10. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.
    Authors: Sassi Et al.
    J Clin Invest  2014;124:5385

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