Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12
values are 2.58, 3.26, > 10 and 28.8 μ
M for NTPDase 1, NTPDase 3, P2Y12
and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
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All Tocris products are intended for laboratory research use only.
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury.
Grenz et al.
FASEB J., 2007;21:2863
The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.
Wall et al.
Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
Muller et al.
The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:
Showing Results 1 - 5 of 5