Chemical Name: Sodium metatungstate
Biological ActivityPOM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
Muller et al.
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury.
Grenz et al.
FASEB J., 2007;21:2863
Citations for POM 1
The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:
12 Citations: Showing 1 - 10
Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients.
Authors: Alvarez-Sanchez Et al.
Sci Rep 2019;9:2302
Kinetics of MSC-based enzyme therapy for immunoregulation.
Authors: Burr and Parekkadan
J Transl Med 2019;17:263
Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances.
Authors: Ohradanova-Repic Et al.
Front Immunol 2018;9:852
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.
Authors: Crittenden Et al.
Immunol Cell Biol 2018;96:1049
CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
Authors: Hirata Et al.
Cell Stem Cell 2018;22:445
The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.
Authors: Del Papa Et al.
Expression of CD39 on activated T cells impairs their survival in older individuals.
Authors: Fang Et al.
Cell Rep. 2016;14:1218
Extracellular ATP protects endothelial cells against DNA damage.
Authors: Aho Et al.
Purinergic Signal 2016;12:575
A dual role for autophagy in a murine model of lung cancer.
Authors: Rao Et al.
Cancer Biol Ther 2014;5:3056
Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.
Authors: Sassi Et al.
J Clin Invest 2014;124:5385
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Authors: Pinheiro Et al.
Cell Commun Signal 2013;11:70
Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
Authors: Yegutkin Et al.
FASEB J 2012;26:3875
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