Catalog # Availability Size / Price Qty
POM 1 | CAS No. 12141-67-2 | NTPDase Inhibitors
1 Image
Description: Inhibitor of E-NTPDases
Alternative Names: Sodium polyoxotungstate

Chemical Name: Sodium metatungstate

Product Details
Citations (12)

Biological Activity

POM 1 is an inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.

Technical Data

Soluble to 100 mM in water
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for POM 1

The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:

12 Citations: Showing 1 - 10

  1. Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients.
    Authors: Alvarez-Sanchez Et al.
    Sci Rep  2019;9:2302
  2. Kinetics of MSC-based enzyme therapy for immunoregulation.
    Authors: Burr and Parekkadan
    J Transl Med  2019;17:263
  3. Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances.
    Authors: Ohradanova-Repic Et al.
    Front Immunol  2018;9:852
  4. Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.
    Authors: Crittenden Et al.
    Immunol Cell Biol  2018;96:1049
  5. CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.
    Authors: Hirata Et al.
    Cell Stem Cell  2018;22:445
  6. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.
    Authors: Del Papa Et al.
    Leukemia  2016;30:1931
  7. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep.  2016;14:1218
  8. Extracellular ATP protects endothelial cells against DNA damage.
    Authors: Aho Et al.
    Purinergic Signal  2016;12:575
  9. A dual role for autophagy in a murine model of lung cancer.
    Authors: Rao Et al.
    Cancer Biol Ther  2014;5:3056
  10. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.
    Authors: Sassi Et al.
    J Clin Invest  2014;124:5385


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for POM 1

There are currently no reviews for this product. Be the first to review POM 1 and earn rewards!

Have you used POM 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.