Catalog Number: 2689
Alternate Names: Sodium polyoxotungstate
Chemical Name: Sodium metatungstate
Biological Activity
Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
Technical Data
  • M.Wt:
    2986.01
  • Formula:
    H2O40Na6W12
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    12141-67-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury.
    Grenz et al.
    FASEB J., 2007;21:2863
  2. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.
    Wall et al.
    , 2008;55:1251
  3. Polyoxometalates - a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
    Muller et al.
    Bioorg.Med.Chem.Lett., 2006;16:5943
Citations:

The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:

5 Citations: Showing 1 - 5
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  1. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.
    Authors: Del Papa Et al.
    Leukemia 2016;30:1931
  2. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep. 2016;14:1218
  3. A dual role for autophagy in a murine model of lung cancer.
    Authors: Rao Et al.
    Cancer Biol Ther 2014;5:3056
  4. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal 2013;11:70
  5. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
    Authors: Yegutkin Et al.
    FASEB J 2012;26:3875

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