POM 1

  ( 7 citations )    
Product Datasheet
Catalog Number:2689
Alternate Names:Sodium polyoxotungstate
Chemical Name:Sodium metatungstate
Product Details
Citations (7)
Reviews
Biological Activity
Inhibitor of Ecto-NTPDases that displays minor selectivity for NTPDases 1 and 2 over NTPDase 3 and P2Y12 (Ki values are 2.58, 3.26, > 10 and 28.8 μM for NTPDase 1, NTPDase 3, P2Y12 and NTPDase 2 respectively). Abolishes renal protection induced by ischemic preconditioning. Inhibits synaptic transmission at hippocampal CA1 pyramidal synapses and at the cerebellar parallel fiber-Purkinje cell (PF) synapse.
Technical Data
  • M.Wt:
    2986.01
  • Formula:
    H2O40Na6W12
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    12141-67-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for POM 1 include:

7 Citations: Showing 1 - 7
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  1. The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.
    Authors: Del Papa Et al.
    Leukemia  2016;30:1931
  2. Expression of CD39 on activated T cells impairs their survival in older individuals.
    Authors: Fang Et al.
    Cell Rep.  2016;14:1218
  3. Extracellular ATP protects endothelial cells against DNA damage.
    Authors: Aho Et al.
    Purinergic Signal  2016;12:575
  4. A dual role for autophagy in a murine model of lung cancer.
    Authors: Rao Et al.
    Cancer Biol Ther  2014;5:3056
  5. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.
    Authors: Sassi Et al.
    J Clin Invest  2014;124:5385
  6. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  7. Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
    Authors: Yegutkin Et al.
    FASEB J  2012;26:3875

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