Pomalidomide 4'-PEG2-amine

Tocris Bioscience | Catalog # 6637

Cereblon ligand with PEG linker and terminal amine for onward chemistry
Tocris Bioscience

Key Product Details

Description

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternative Names

Pomalidomide - linker 1
View all Degrader Building Blocks »

Product Description

Pomalidomide 4'-PEG2-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

This product has been recently renamed. The previous name for this product was Pomalidomide - linker 1

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Pomalidomide 4'-PEG2-amine

Molecular Weight

440.88

Formula

C19H24N4O6.HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride

CAS Number

2245697-87-2

PubChem ID

134812848

InChI Key

BIBZEYIXXZHGNZ-UHFFFAOYSA-N

SMILES

NCCOCCOCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for Pomalidomide 4'-PEG2-amine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pomalidomide 4'-PEG2-amine

For research use only

Customer Reviews for Pomalidomide 4'-PEG2-amine (1)

5 out of 5
1 Customer Rating
5 Stars
100%
4 Stars
0%
3 Stars
0%
2 Stars
0%
1 Stars
0%

Have you used Pomalidomide 4'-PEG2-amine?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card

Customer Images

Showing  1 - 1 of 1 review Showing All
Filter By:
Clear Filters X
  • Targeted protein degradation
    Name: Sandipan Roy Chowdhury
    Species: cells
    Assay Type: In Vitro
    Cell Line/Tissue: MCF7
    Verified Customer | Posted 05/20/2020
    to make protacs
    Pomalidomide 4'-PEG2-amine 6637

There are no reviews that match your criteria.

Showing  1 - 1 of 1 review Showing All