PPM-3

Key Product Details

Product Description

PPM-3 is a potent and selective ERK5 Degrader (PROTAC^®) (IC₅₀ = 62.4 nM). PPM-3 degrades ERK5 in HCT116, h1975, HepG2, MDA-MB-231, PC-3, and A375 tumor cell lines (DC₅₀ values are 5.6, 11.5, 13.7, 22.7, 23.5 and 41.4 nM respectively). PPM-3 has no effect on tumor cell growth directly but influences tumor development by affecting the differentiation of macrophages.

Product Specifications for PPM-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PPM-3

The following data is based on the product molecular weight 1000.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.00 mL	5.00 mL	10.00 mL
5 mM	0.20 mL	1.00 mL	2.00 mL
10 mM	0.10 mL	0.50 mL	1.00 mL
50 mM	0.02 mL	0.10 mL	0.20 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Pan Design, synthesis, and biological evaluation of proteolysis-targeting chimeras as highly selective and efficient degraders of extracellular signal-regulated kinase 5. J.Med.Chem. 2023 PMID: 37751283

Product Documents for PPM-3