Potent, voltage-independent CFTR chloride channel inhibitor (IC50
= 90 nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro
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Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model.
Tradtrantip et al.
CFTR dysfunction induces vascular endothelial growth factor synthesis in airway epithelium.
Martin et al.