Catalog Number: 4482
Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine
Biological Activity
Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
Technical Data
  • M.Wt:
    223.28
  • Formula:
    C7H5N5S2
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    2645-32-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
    Altun et al.
    Chem.Biol., 2011;18:1401
  2. The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.
    Seiberlich et al.
    Biochim.Biophys.Acta, 2012;1823:2057

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