Chemical Name: 2,6-Diamino-3,5-dithiocyanopyridine
Biological ActivityBroad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.
Seiberlich et al.
Citation for PR 619
The citations listed below are publications that use Tocris products. Selected citations for PR 619 include:
1 Citation: Showing 1 - 1
The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology.
Authors: Saldate Et al.
J Biol Chem 2018;293:2232
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