Broad spectrum, reversible DUB inhibitor. Exhibits limited activity against other proteases. Induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. Cytotoxic in HEK293T and colorectal cancer cells. Stabilizes microtubule network in oligodendroglial cells.
Soluble to 10 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun et al.
The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.
Seiberlich et al.