hh Pramipexole dihydrochloride (CAS 104632-25-9): R&D Systems
Catalog Number: 4174
Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Biological Activity
Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.
Technical Data
  • M.Wt:
    284.25
  • Formula:
    C10H17N3S.2HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    104632-25-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors.
    Mierau et al.
    Eur.J.Pharmacol., 1995;290:29
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:

2 Citations: Showing 1 - 2
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  1. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    J Exp Bot 2015;11:2057
  2. A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions.
    Authors: Bonito-Oliva Et al.
    Front Behav Neurosci 2014;8:290

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