Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Biological ActivityPramipexole dihydrochloride is a dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pramipexole binding and activation of cloned and expressed DA D2, D3 and D4 receptors.
Mierau et al.
Citations for Pramipexole dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:
2 Citations: Showing 1 - 2
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
J Exp Bot 2015;11:2057
A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions.
Authors: Bonito-Oliva Et al.
Front Behav Neurosci 2014;8:290
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