Pravastatin sodium salt
Chemical Name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
Biological ActivityWater-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (Ki~ 1 nM) and displays cardioprotective properties.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors.
Hamelin and Turgeon
Citations for Pravastatin sodium salt
The citations listed below are publications that use Tocris products. Selected citations for Pravastatin sodium salt include:
3 Citations: Showing 1 - 3
AMP-Activated Protein Kinase Alpha 2 Deletion Induces VSMC Phenotypic Switching and Reduces Features of Atherosclerotic Plaque Stability.
Authors: Ding Et al.
Circ Res 2016;119:718
Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis.
Authors: Rojo-Arreola Et al.
PLoS One 2014;9:e87594
Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by STAT.
Authors: Vainio Et al.
Proc Natl Acad Sci U S A 2011;2:1176
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