PRE-084 hydrochloride

Catalog # Availability Size / Price Qty
0589/10
0589/50
Sigma1 Receptor Agonists Small Molecule
1 Image
Description: Highly selective σ1 agonist

Chemical Name: 2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride

Purity: ≥99%

Product Details
Citations (17)
Reviews

Biological Activity

High affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). Selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling.

Technical Data

M.Wt:
353.89
Formula:
C19H27NO3.HCl
Solubility:
Soluble to 25 mM in water and to 75 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
138847-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for PRE-084 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PRE-084 hydrochloride include:

17 Citations: Showing 1 - 10

  1. Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.
    Authors: Brailoiu Et al.
    Cell Rep  2019;26:330
  2. The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.
    Authors: Sánchez-Blázquez Et al.
    Mol Neurobiol  2018;55:4940
  3. Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
    Authors: Sánchez-Blázquez Et al.
    Int J Neuropsychopharmacol  2018;21:938
  4. Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
    Authors: Rodríguez-Muñoz Et al.
    Mol Brain  2018;11:51
  5. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy.
    Authors: Atzmon Et al.
    Front Mol Neurosci  2018;11:336
  6. The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
    Authors: Rodríguez-Muñoz Et al.
    Br J Pharmacol  2015;6:35458
  7. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    Br J Ophthalmol  2015;35:6639
  8. The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
    Authors: Malik Et al.
    Int J Neuropsychopharmacol  2015;172:2519
  9. Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells.
    Authors: Szabo Et al.
    PLoS One  2014;9:e106533
  10. Cocaine disrupts histamine H3 receptor modulation of DA D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.
    Authors: Moreno Et al.
    J Neurosci  2014;34:3545

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