PRE-084 hydrochloride

Tocris Bioscience | Catalog # 0589

Highly selective σ1 agonist
Tocris Bioscience

Key Product Details

Description

Highly selective σ1 agonist
View all Sigma1 Receptor Agonists »

Product Description

PRE-084 hydrochloride is a high affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). Selective over PCP receptors (IC50 > 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κB signaling.

Product Specifications for PRE-084 hydrochloride

Molecular Weight

353.89

Formula

C19H27NO3.HCl

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

2-(4-Morpholinethyl) 1-phenylcyclohexanecarboxylate hydrochloride

CAS Number

138847-85-5

PubChem ID

11314197

InChI Key

QUJWFJNHTBKCLU-UHFFFAOYSA-N

SMILES

Cl.O=C(OCCN1CCOCC1)C1(CCCCC1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25
DMSO 26.54 75

Preparing Stock Solutions for PRE-084 hydrochloride

The following data is based on the product molecular weight 353.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.77 mL 18.84 mL 37.68 mL
3.75 mM 0.75 mL 3.77 mL 7.54 mL
7.5 mM 0.38 mL 1.88 mL 3.77 mL
37.5 mM 0.08 mL 0.38 mL 0.75 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 35 publications citing the usage of this product.

Product Documents for PRE-084 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PRE-084 hydrochloride

For research use only

Citations for PRE-084 hydrochloride

Customer Reviews for PRE-084 hydrochloride (2)

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  • Consistent Reproducible Results
    Name: Zeinab Motawe
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human Umbilical Vein Endothelial Cells (HUVECs)
    Verified Customer | Posted 05/19/2020
    I used it to test the effects of sigma-1 receptor activation on glycolysis in endothelial cells using Agilent seahorse XFp instrument (Agilent Technologies, Santa Clara, CA, USA)
  • Worked great for all assays used
    Name: Zeinab Motawe
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Human Dermal Microvascular Endothelial Cells (HDMEC)
    Verified Customer | Posted 05/09/2020
    I diluted it with water and made stock solutions of 10 mM. Stocks were kept in -20.
    I used it to test its effect on trans-endothelial electrical resistance (TER) of human dermal microvascular endothelial cells (HDMEC) which gives an idea about endothelial barrier using electrical cell substrate impedance sensing (ECIS). HDMEC (Lifeline cell technologies Frederick, MD, USA) were seeded on ECIS microarrays (applied physics, Troy, NY, USA), grown till confluence. Then cells were serum starved for 1 hour and different concentrations of PRE-084 were added. TER was recorded over time. The graph showed TER differences at 8 hours. n=4/group. Analysis was done by One-Way ANOVA followed by Dunnett's multiple comparison test. *p<0.05. **p<0.005, ***p<0.0005
    PRE-084 hydrochloride 0589

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