High affinity, selective σ1
values are 2.2 and 13091 nM for σ1
receptors respectively). Selective over PCP receptors (IC50
> 100000 nM) and several other receptor systems. Produces antiamnesic and antitussive effects in vivo
. Also exhibits protective effects in PC6.3 cells expressing mutant huntingtin by activating NF-κ
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All Tocris products are intended for laboratory research use only.
Antitussive activity of sigma-1 receptor agonists in the guinea-pig.
Brown et al.
Sigma compounds derived from phencyclidine. Identification of PRE-084, a new selective sigma ligand.
Su et al.
The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (σ) receptor ligands involves both σ1 and σ2 sites.
Maurice et al.
Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway.
Hyrskyluoto et al.
Cell Death Dis., 2013;4:e646
The citations listed below are publications that use Tocris products. Selected citations for PRE-084 hydrochloride include:
Showing Results 1 - 10 of 11