Highly potent neurosteroid; enhances intracellular Ca2+
upon NMDA receptor-mediated synaptic activity (EC50
= ~2 pM) and potentiates NMDA responses. Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.
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All Tocris products are intended for laboratory research use only.
Neuroactive steroids and human recombinant rho1 GABAC receptors.
Li et al.
Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.
Majeed et al.
A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
Smith et al.
The citations listed below are publications that use Tocris products. Selected citations for Pregnenolone sulfate sodium salt include:
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