Catalog Number: 5376
Chemical Name: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
Biological Activity
Highly potent neurosteroid; enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 = ~2 pM) and potentiates NMDA responses. Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.
Technical Data
  • M.Wt:
    418.52
  • Formula:
    C21H31NaO5S
  • Solubility:
    Soluble to 10 mM in water with sonication and to 100 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    1852-38-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuroactive steroids and human recombinant rho1 GABAC receptors.
    Li et al.
    J.Pharmacol.Exp.Ther., 2007;323:236
  2. Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.
    Majeed et al.
    Br.J.Pharmacol., 2010;161:430
  3. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
    Smith et al.
    Mol.Pharmacol., 2014;86:390
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Pregnenolone sulfate sodium salt include:

1 Citations: Showing 1 - 1

  1. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
    Authors: Luoma Et al.
    Steroids 2011;76:845

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