Pregnenolone sulfate sodium salt

Tocris Bioscience | Catalog # 5376

NMDA potentiator; also GABAA inhibitor and TRPM3 activator
Tocris Bioscience

Key Product Details

Description

NMDA potentiator; also GABAA inhibitor and TRPM3 activator
View all Additional NMDA Receptor Compounds »

Product Description

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Product Specifications for Pregnenolone sulfate sodium salt

Molecular Weight

418.52

Formula

C21H31NaO5S

Storage

Store at +4°C

Chemical Name

(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

CAS Number

1852-38-6

PubChem ID

23676306

InChI Key

QQVJEIZJHDPTSH-UTNKIXDHSA-M

SMILES

O=[C@](C)[C@H]4CC[C@@]3([H])[C@]2([H])CC=C1C[C@@H](OS(=O)([O-])=O)CC[C@@](C)1[C@]([H])2CC[C@@]34C.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.93 50

Preparing Stock Solutions for Pregnenolone sulfate sodium salt

The following data is based on the product molecular weight 418.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.78 mL 23.89 mL 47.79 mL
2.5 mM 0.96 mL 4.78 mL 9.56 mL
5 mM 0.48 mL 2.39 mL 4.78 mL
25 mM 0.10 mL 0.48 mL 0.96 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for Pregnenolone sulfate sodium salt

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pregnenolone sulfate sodium salt

For research use only

Citations for Pregnenolone sulfate sodium salt

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