Pregnenolone sulfate sodium salt

Catalog # Availability Size / Price Qty
5376/50

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Pregnenolone sulfate sodium salt | CAS No. 1852-38-6 | Additional NMDA Receptor Compounds
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Description: NMDA potentiator; also GABAA inhibitor and TRPM3 activator

Chemical Name: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

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Citations (1)
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Biological Activity

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Technical Data

M.Wt:
418.52
Formula:
C21H31NaO5S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at +4°C
CAS No:
1852-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Pregnenolone sulfate sodium salt

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