Chemical Name: 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
Biological ActivityPridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ~30-fold and ~100-fold selectivity over the dopamine D3 receptor and the D2 receptor, respectively. Pridopidine is a low affinity dopamine D2 receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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