Probucol

Tocris Bioscience | Catalog # 2775

ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
Tocris Bioscience
Discontinued Product
2775 has been discontinued. View all Additional Antioxidant Compounds products.

Key Product Details

Description

ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
View all Additional Antioxidant Compounds »

Product Description

Probucol is an ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.

Product Specifications for Probucol

Molecular Weight

516.84

Formula

C31H48O2S2

Storage

Desiccate at +4°C

Purity

≥99% (HPLC)

Chemical Name

4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]

CAS Number

23288-49-5

PubChem ID

4912

InChI Key

FYPMFJGVHOHGLL-UHFFFAOYSA-N

SMILES

CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.92 25
Ethanol 51.68 100

Preparing Stock Solutions for Probucol

The following data is based on the product molecular weight 516.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.67 mL 19.35 mL
5 mM 0.39 mL 1.93 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Calculators

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Product Documents for Probucol

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Probucol

For research use only

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