Probucol
Discontinued Product
Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity: ≥99%
Biological Activity
Probucol is an ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice.
Wu et al.
J.Pharmacol.Exp.Ther., 2007;321:477 -
Probucol inhibits ABCA1-mediated cellular lipid efflux.
Favari et al.
Arterioscler.Thromb.Vasc.Biol., 2004;24:2345 -
Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation.
Wu et al.
J.Biol.Chem., 2004;279:30168 -
Pretreatment with prob. attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion.
Ruixing et al.
Scand.J.Clin.Lab.Invest., 2006;66:549
Product Datasheets
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Citation for Probucol
The citations listed below are publications that use Tocris products. Selected citations for Probucol include:
1 Citation: Showing 1 - 1
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
Authors: Guo Et al.
Nat Commun 2016;7:12646
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