Proglumide sodium salt
Chemical Name: 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid sodium salt
Biological ActivityProglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini.
Iwamoto et al.
Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells.
Mauss et al.
Anticancer Res., 1994;14:215
Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists.
Hahne et al.
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