Catalog Number: 4998
Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
Biological Activity
DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
    Ogawa et al.
    Nat.Commun., 2010;1:86

The citations listed below are publications that use Tocris products. Selected citations for ProINDY include:

Showing Results 1 - 1 of 1

  1. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
    Authors: Seu Et al.
    Sci Rep
Tocris Small Molecules
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