Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
Biological ActivityDYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.
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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Ogawa et al.
Citations for ProINDY
The citations listed below are publications that use Tocris products. Selected citations for ProINDY include:
2 Citations: Showing 1 - 2
A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
Authors: Kim Et al.
Dis Model Mech 2016;9:839
Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
Authors: Seu Et al.
Sci Rep 2015;89:6656
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