INDY
Chemical Name: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98%
Biological Activity
INDY is a DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Ogawa et al.
Nat.Commun., 2010;1:86 -
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
Pozo et al.
J.Clin.Invest., 2013;123:2475
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Citations for INDY
The citations listed below are publications that use Tocris products. Selected citations for INDY include:
4 Citations: Showing 1 - 4
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Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function.
Authors: Wahl Et al.
BMC Genomics 2018;19:795
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A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
Authors: Kim Et al.
Dis Model Mech 2016;9:839
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Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
Authors: Seu Et al.
J Virol 2015;89:6656
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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
Authors: Wang Et al.
Nat Med 2015;21:383
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