Catalog Number: 4997
Chemical Name: (1Z)-1-(3-Ethyl-5-hydroxy-2(3H)-benzothiazolylidene)-2-propanone
Biological Activity
DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).
Technical Data
  • M.Wt:
    235.3
  • Formula:
    C12H13NO2S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1169755-45-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
    Ogawa et al.
    Nat.Commun., 2010;1:86
  2. Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
    Pozo et al.
    J.Clin.Invest., 2013;123:2475
Citations:

The citations listed below are publications that use Tocris products. Selected citations for INDY include:

2 Citations: Showing 1 - 2
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  1. Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
    Authors: Seu Et al.
    J Virol 2015;89:6656
  2. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
    Authors: Wang Et al.
    Nat Med 2015;21:383
Tocris Small Molecules
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ProINDY

4998 1  
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