DYRK1A/B inhibitor (IC50
values are 0.23 and 0.24 μ
M, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY
(Cat. No. 4998).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Ogawa et al.
Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth.
Pozo et al.
The citations listed below are publications that use Tocris products. Selected citations for INDY include:
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