INDY

Key Product Details

Product Description

INDY is a DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

Product Specifications for INDY

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for INDY

The following data is based on the product molecular weight 235.30.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.25 mL	21.25 mL	42.50 mL
5 mM	0.85 mL	4.25 mL	8.50 mL
10 mM	0.42 mL	2.12 mL	4.25 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Ogawa Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. Nat.Commun. 2010 PMID: 20981014
• Pozo Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J.Clin.Invest. 2013 PMID: 23635774

Product Documents for INDY