proTAME

Key Product Details

Product Description

ProTAME is a cell-permeable APC/C (anaphase-promoting complex/cyclosome) inhibitor. It is converted to TAME (Tosyl-L-Arginine Methyl Ester) by intracellular esterases. It induces cell cycle arrest in metaphase followed by cell death.

Product Specifications for proTAME

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for proTAME

The following data is based on the product molecular weight 726.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.75 mL	13.76 mL	27.52 mL
2.5 mM	0.55 mL	2.75 mL	5.50 mL
5 mM	0.28 mL	1.38 mL	2.75 mL
25 mM	0.06 mL	0.28 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Zeng Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010 PMID: 20951947

Product Documents for proTAME