3.1 channel blocker (IC50
values are 0.2 and 31.8 μ
M for hCaV
3.1 and hCaV
3.2 respectively). Also reversibly inhibits NaV
1.8 and blocks KV
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2.
Ohkubo et al.
T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.
Ohkubo and Yamazaki
Two tarantula peptides inhibit activation of multiple sodium channels.
Middleton et al.