ProTx I

Name: ProTx I
Brand: Tocris Bioscience
SKU: 4665

Tocris Bioscience | Catalog # 4665

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Product Documents

CaV3.1 blocker; also inhibits NaV1.8 and KV2.1

Discontinued Product

4665 has been discontinued. View all Cav3.x Channel Blockers products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

CaV3.1 blocker; also inhibits NaV1.8 and KV2.1

View all Cav3.x Channel Blockers »

Product Description

ProTx I is a selective Ca_V3.1 channel blocker (IC₅₀ values are 0.2 and 31.8 μM for hCa_V3.1 and hCa_V3.2 respectively). Also reversibly inhibits Na_V1.8 and blocks K_V2.1 channels.

Product Specifications for ProTx I

Molecular Weight

3987.51

Formula

C₁₇₁H₂₄₅N₅₃O₄₇S₆

Storage

Store at -20°C

CAS Number

484598-35-8

PubChem ID

90488963

InChI Key

TYAZSKURKBASCY-UHFFFAOYSA-N

SMILES

[H]N[C@@H](CCC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)CNC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCN)NC2=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Ohkubo and Yamazaki T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells. Int.J.Oncol. 2012 PMID: 22469755
Middleton Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 2002 PMID: 12475222
Ohkubo Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2. J.Pharmacol.Sci. 2010 PMID: 20351484

Product Documents for ProTx I

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ProTx I

For research use only

Related Research Areas

Ion Channels and Regulators

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