PS 1145 dihydrochloride

Discontinued Product

4569 has been discontinued.
View all IkB Kinase Inhibitors products.
PS 1145 dihydrochloride | CAS No. 1049743-58-9 | IkB Kinase Inhibitors
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Description: Selective IKK inhibitor; orally active

Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

Purity: ≥98%

Product Details
Citations (4)

Biological Activity

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

Technical Data

Soluble to 5 mM in DMSO with gentle warming
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel IKK inhibitors: beta-carbolines.
    Castro et al.
    Bioorg.Med.Chem.Lett., 2003;13:2419
  2. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
    Newton et al.
    J.Pharmacol.Exp.Ther., 2007;321:734
  3. NF-kappa B as a therapeutic target in multiple myeloma.
    Hideshima et al.
    J.Biol.Chem., 2002;277:16639

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Citations for PS 1145 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PS 1145 dihydrochloride include:

4 Citations: Showing 1 - 4


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