PS 1145 dihydrochloride

   
Product Datasheet
Catalog Number:4569
Chemical Name:N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
Product Details
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Biological Activity
Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.
Technical Data
  • M.Wt:
    395.67
  • Formula:
    C17H11ClN4O.2HCl
  • Solubility:
    Soluble to 5 mM in DMSO with gentle warming
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    1049743-58-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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