PS 1145 dihydrochloride

Catalog # Availability Size / Price Qty
4569/10
4569/50
Cat.No. 4569 - PS 1145 dihydrochloride | CAS No. 1049743-58-9
1 Image
Description: Selective IKK inhibitor; orally active

Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

Technical Data

M.Wt:
395.67
Formula:
C17H11ClN4O.2HCl
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1049743-58-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Novel IKK inhibitors: beta-carbolines.
    Castro et al.
    Bioorg.Med.Chem.Lett., 2003;13:2419
  2. Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
    Newton et al.
    J.Pharmacol.Exp.Ther., 2007;321:734
  3. NF-kappa B as a therapeutic target in multiple myeloma.
    Hideshima et al.
    J.Biol.Chem., 2002;277:16639

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PS 1145 dihydrochloride

There are currently no reviews for this product. Be the first to review PS 1145 dihydrochloride and earn rewards!

Have you used PS 1145 dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.