PS 1145 dihydrochloride
Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
Biological ActivityPS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel IKK inhibitors: beta-carbolines.
Castro et al.
Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors.
Newton et al.
NF-kappa B as a therapeutic target in multiple myeloma.
Hideshima et al.
Citation for PS 1145 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PS 1145 dihydrochloride include:
1 Citation: Showing 1 - 1
Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth.
Authors: Gari Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PS 1145 dihydrochloride
There are currently no reviews for this product. Be the first to review PS 1145 dihydrochloride and earn rewards!
Have you used PS 1145 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image