PS 1145 dihydrochloride

Key Product Details

Product Description

PS 1145 dihydrochloride is a selective IκB kinase (IKK) inhibitor (IC₅₀ = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

Product Specifications for PS 1145 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PS 1145 dihydrochloride

The following data is based on the product molecular weight 395.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	50.55 mL	252.74 mL	505.47 mL
0.25 mM	10.11 mL	50.55 mL	101.09 mL
0.5 mM	5.05 mL	25.27 mL	50.55 mL
2.5 mM	1.01 mL	5.05 mL	10.11 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Newton Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors. J.Pharmacol.Exp.Ther. 2007 PMID: 17322026
• Hideshima NF-kappa B as a therapeutic target in multiple myeloma. J.Biol.Chem. 2002 PMID: 11872748
• Castro Novel IKK inhibitors: beta-carbolines. Bioorg.Med.Chem.Lett. 2003 PMID: 12824047

Product Documents for PS 1145 dihydrochloride