PSB 12379

Name: PSB 12379
Brand: Tocris Bioscience
SKU: 6083
Price: 414 USD
Availability: InStock

Tocris Bioscience | Catalog # 6083

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Citations (10)

Product Documents

Ecto-5'-nucleotidase (CD73) inhibitor

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Ecto-5'-nucleotidase (CD73) inhibitor

View all Other ATPase Inhibitors »

Product Description

PSB 12379 is a selective high affinity ecto-5'-nucleotidase/CD73 inhibitor (K_i values are 2.21 and 9.03 nM at human and rat CD73, respectively). Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Exhibits selectivity over other ecto-nucleotidases and ADP-activated P2Y receptors tested.

Product Specifications for PSB 12379

Molecular Weight

559.31

Formula

C₁₈H₂₁N₅Na₂O₉P₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N⁶-Benzyl-α,β-methyleneadenosine 5'-diphosphate disodium salt

PubChem ID

131648246

InChI Key

CGXINRNHTNDEBI-BUPZQQHBSA-L

SMILES

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@@H]1COP(CP(O)(O[Na])=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Calculators

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Mass

Concentration

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

Weinmann Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 2016 PMID: 26836578
Bhattarai α,β-methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5'-nucleotidase (CD73) inhibitors. J.Med.Chem. 2015 PMID: 26147331

Product Documents for PSB 12379

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PSB 12379

For research use only

Citations for PSB 12379

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