Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β
linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.
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The third helix of the Antennapedia homeodomain translocates through biological membranes.
Derossi D, Joliot AH, Chassaing G, Prochiantz A.
J Biol Chem.
An autoregulatory region in protein kinase C: the pseudoanchoring site.
Ron and Mochly-Rosen
Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
Theodore et al.