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Pseudo RACK1

1790 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1790/1
Pseudo RACK1
1 Image
Description: Protein kinase C activator peptide (attached to cell permeable vector)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Technical Data

M.Wt:
3198.81
Formula:
C144H225N43O34S3
Sequence:
KKWKMRRNQFWIKIQRC CSVEIWD*

(Modifcations: Disulfide bridge between 17 -1*)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The third helix of the Antennapedia homeodomain translocates through biological membranes.
    Derossi D, Joliot AH, Chassaing G, Prochiantz A.
    J Biol Chem.
  2. An autoregulatory region in protein kinase C: the pseudoanchoring site.
    Ron and Mochly-Rosen
    Proc.Natl.Acad.Sci.U.S.A., 1995;92:492
  3. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
    Theodore et al.
    J.Neurosci., 1995;15:7158

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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