Pseudo RACK1

Biological Activity

Pseudo RACK1 is an activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The third helix of the Antennapedia homeodomain translocates through biological membranes.
   Derossi D, Joliot AH, Chassaing G, Prochiantz A.
   J Biol Chem.
2. An autoregulatory region in protein kinase C: the pseudoanchoring site.
   Ron and Mochly-Rosen
   Proc.Natl.Acad.Sci.U.S.A., 1995;92:492
3. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
   Theodore et al.
   J.Neurosci., 1995;15:7158

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