Catalog Number: 1790
Biological Activity
Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.
Technical Data
  • M.Wt:
    3198.81
  • Formula:
    C144H225N43O34S3
  • Sequence:
    KKWKMRRNQFWIKIQRC CSVEIWD*

    (Modifcations: Disulfide bridge between 17 -1*)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The third helix of the Antennapedia homeodomain translocates through biological membranes.
    Derossi D, Joliot AH, Chassaing G, Prochiantz A.
    J Biol Chem.
  2. An autoregulatory region in protein kinase C: the pseudoanchoring site.
    Ron and Mochly-Rosen
    Proc.Natl.Acad.Sci.U.S.A., 1995;92:492
  3. Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
    Theodore et al.
    J.Neurosci., 1995;15:7158

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