Biological ActivityPseudo RACK1 is an activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.
(Modifcations: Disulfide bridge between 17 -1*)
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The third helix of the Antennapedia homeodomain translocates through biological membranes.
Derossi D, Joliot AH, Chassaing G, Prochiantz A.
J Biol Chem.
An autoregulatory region in protein kinase C: the pseudoanchoring site.
Ron and Mochly-Rosen
Intraneuronal delivery of protein kinase C pseudosubstrate leads to growth cone collapse.
Theodore et al.
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