PU H71

Catalog # Availability Size / Price Qty
3104/10
PU H71 | CAS No. 873436-91-0 | HSP90 Inhibitors
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Description: Potent Hsp90 inhibitor

Chemical Name: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

Purity: ≥98%

Product Details
Citations (4)
Reviews

Biological Activity

Potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

Technical Data

M.Wt:
512.37
Formula:
C18H21IN6O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
873436-91-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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