Potent inhibitor of heat shock protein 90 (Hsp90) (IC50
= 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50
values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
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All Tocris products are intended for laboratory research use only.
Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
Chan CT, Paulmurugan R, Gheysens OS et al.
Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
He et al.
Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
Caldas-Lopes et al.