Catalog Number: 3104
Chemical Name: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
Biological Activity
Potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.
Technical Data
  • M.Wt:
    512.37
  • Formula:
    C18H21IN6O2S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    873436-91-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.
    Chan CT, Paulmurugan R, Gheysens OS et al.
    Cancer Res
  2. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.
    He et al.
    J.Med.Chem., 2006;49:381
  3. Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models.
    Caldas-Lopes et al.
    Proc.Natl.Acad.Sci.USA, 2009;106:8368

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