Pyr 10

Tocris Bioscience | Catalog # 6941

Selective TRPC3 inhibitor
Tocris Bioscience

Key Product Details

Description

Selective TRPC3 inhibitor
View all TRPC Channel Blockers »

Product Description

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

Product Specifications for Pyr 10

Molecular Weight

449.37

Formula

C18H13F6N3O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide

CAS Number

1315323-00-2

PubChem ID

53475435

InChI Key

CVALMMCIOLXHDM-UHFFFAOYSA-N

SMILES

CC1=CC=C(S(=O)(NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Ethanol 44.94 100

Preparing Stock Solutions for Pyr 10

The following data is based on the product molecular weight 449.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Pyr 10

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pyr 10

For research use only

Related Research Areas

Ion Channels and Regulators

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  • Inhibits TRPC3 channel
    Name: Yuyang Sun
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: PC12
    Verified Customer | Posted 05/30/2022
    Used pyr to inhibit TRPC3 channel in PC12 cells. It can inhibit OAG induced TRPC3 current.

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