Catalog Number: 0727
Alternate Names: PDTC
Biological Activity
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.
Technical Data
  • M.Wt:
    164.28
  • Formula:
    C5H12N2S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    5108-96-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.
    Bessho et al.
    Biochem.Pharmacol., 1994;48:1883
  2. Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells.
    Eberhardt et al.
    Biochem.Biophys.Res.Commun., 1994;200:163
  3. Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta.
    Schini-Kerth
    Eur.J.Pharmacol., 1994;265:83

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