Pyrrolidinedithiocarbamate ammonium

Tocris Bioscience | Catalog # 0727

Inhibits NF-κB, prevents increase in NOS mRNA
Tocris Bioscience
Discontinued Product
0727 has been discontinued. View all NFkB/IkB Inhibitors products.

Key Product Details

Description

Inhibits NF-κB, prevents increase in NOS mRNA

Alternative Names

PDTC
View all NFkB/IkB Inhibitors »

Product Description

This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.

Product Specifications for Pyrrolidinedithiocarbamate ammonium

Molecular Weight

164.28

Formula

C5H12N2S2

Storage

Store at RT

CAS Number

5108-96-3

PubChem ID

73343

InChI Key

MDDIUTVUBYEEEM-UHFFFAOYSA-N

SMILES

[NH4+].[S-]C(N1CCCC1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.43 100

Preparing Stock Solutions for Pyrrolidinedithiocarbamate ammonium

The following data is based on the product molecular weight 164.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.09 mL 30.44 mL 60.87 mL
5 mM 1.22 mL 6.09 mL 12.17 mL
10 mM 0.61 mL 3.04 mL 6.09 mL
50 mM 0.12 mL 0.61 mL 1.22 mL

Calculators

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Product Documents for Pyrrolidinedithiocarbamate ammonium

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pyrrolidinedithiocarbamate ammonium

For research use only

Citations for Pyrrolidinedithiocarbamate ammonium

Customer Reviews for Pyrrolidinedithiocarbamate ammonium (1)

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  • PDTC inhibits HOCl-LDL-induced CaMKII oxidation
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Cardiomyocytes
    Verified Customer | Posted 10/22/2018
    HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.
    Pyrrolidinedithiocarbamate ammonium 0727

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