Biological ActivityThis inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP.
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Pyrrolidine dithiocarbamate, a potent inhibitor of nuclear factor κB (NF-κB) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes.
Bessho et al.
Pyrrolidine dithiocarbamate differentially affects 1β- and cAMP-induced NO-synthase expression in rat renal mesangial cells.
Eberhardt et al.
Pyrrolidine dithiocarbamate selectively prevents the expression of the inducible nitric oxide synthase in the rat aorta.
Citations for Pyrrolidinedithiocarbamate ammonium
The citations listed below are publications that use Tocris products. Selected citations for Pyrrolidinedithiocarbamate ammonium include:
8 Citations: Showing 1 - 8
IL-17A causes depression-like symptoms via NFκB and p38MAPK signaling pathways in mice: Implications for psoriasis associated depression.
Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression.
Authors: Li Et al.
PAFR activation of NF-& #954;B p65 or p105 precursor dictates pro-and anti-inflammatory responses during TLR activation in murine macrophages
Authors: Ishizuka Et al.
Scientific Reports 2016;6:32092
Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis.
Authors: Lin Et al.
J Neurosci 2015;5:12463
Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling.
Authors: Wang Et al.
Sci Rep 2015;15:821
CD31 is a key coinhibitory receptor in the development of immunogenic dendritic cells.
Authors: Clement Et al.
Proc Natl Acad Sci U S A 2014;111:E1101
NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene.
Authors: Muxel Et al.
BMC Cancer 2013;7:e52010
Novel mechanism for obesity-induced colon cancer progression.
Authors: Birmingham Et al.
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HL-1 cardiomyocytes were pre-treated with Pyrrolidinedithiocarbamate (PDTC, 1 mM), Tempol (1 mM) or N-Acetylcysteine (NAC, 1 mM) for 30 min and stimulated with HOCl-LDL (200 µg/ml) for 2 h to follow CaMKII oxidation using Western blot.