Chemical Name: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Biological ActivityQAQ dichloride is a photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Photochromic blockers of voltage-gated potassium channels.
Banghart MR et al.
Rapid optical control of nociception with an ion-channel photoswitch.
Mourot et al.
Citations for QAQ dichloride
The citations listed below are publications that use Tocris products. Selected citations for QAQ dichloride include:
2 Citations: Showing 1 - 2
Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors.
Authors: Nikolaev Et al.
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