channel blocker. Blocks channels in the trans
conformation. Switches conformation from cis
at 500 nm and trans
at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
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All Tocris products are intended for laboratory research use only.
Photochromic blockers of voltage-gated potassium channels.
Banghart et al.
Rapid optical control of nociception with an ion-channel photoswitch.
Mourot et al.