QNZ 46 (CAS 1237744-13-6): R&D Systems
Catalog Number: 4801
Chemical Name: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
Biological Activity
NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). Requires binding of glutamate to the GluN2 subunit.
Technical Data
  • M.Wt:
    443.41
  • Formula:
    C24H17N3O6
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    1237744-13-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors.
    Hansen and Traynelis
    J.Neurosci., 2011;31:3650
  2. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.
    Mosley et al.
    J.Med.Chem., 2010;53:5476

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