7 channel opener (EC50
values are 0.6, 1.0, 5.2 and 7.0 μ
M for Kv
7.3/7.5 and Kv
7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58.
Zhang et al.
Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators.
Qi et al.