QO 58

Catalog # Availability Size / Price Qty
5083/50
5083/10
Cat.No. 5083 - QO 58 | C18H8Cl2F4N4O | CAS No. 1259536-62-3
1 Image
Description: Kv7 channel opener

Chemical Name: 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

Purity: ≥98%

Product Details
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Biological Activity

Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

Technical Data

M.Wt:
443.18
Formula:
C18H8Cl2F4N4O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1259536-62-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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