QO 58

Catalog # Availability Size / Price Qty
5083/50
5083/10
Voltage-gated Potassium Channel Activators Small Molecule
1 Image
Description: Kv7 channel opener

Chemical Name: 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

Technical Data

M.Wt:
443.18
Formula:
C18H8Cl2F4N4O
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1259536-62-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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QO 58 used for to understand channel opening properties
By Anonymous on 10/13/2018
Species: Human

Our University lab used this product for years to study channel opening properties. Worked great on lab conditions and shows different rates on channel opening on different cell lines. Great product, would buy again and recommend.


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