QS 11

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3324/50
QS 11 | CAS No. 944328-88-5 | ARF GTPase Inhibitors
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Description: ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling

Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews

Biological Activity

GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.

Technical Data

M.Wt:
567.68
Formula:
C36H33N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
944328-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A chemical approach to stem cell biology
    Emre et al.
    Curr.Opin.Chem.Biol., 2007;11:252
  2. Small-molecule synergist of the Wnt/β-catenin signaling pathway.
    Zhang et al.
    Proc.Natl.Acad.Sci.USA, 2007;104:7444

Product Datasheets

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Citations for QS 11

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2 Citations: Showing 1 - 2

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