Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Biological ActivityQS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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A chemical approach to stem cell biology
Emre et al.
Small-molecule synergist of the Wnt/β-catenin signaling pathway.
Zhang et al.
Citations for QS 11
The citations listed below are publications that use Tocris products. Selected citations for QS 11 include:
2 Citations: Showing 1 - 2
Mutant Isocitrate Dehydrogenase 1 Disrupts PKM2-β-Catenin-BRG1 Transcriptional Network-Driven CD47 Expression.
Authors: Gowda Et al.
Mol Cell Biol 2018;38
Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles
Authors: Wu, J Et al.
Scientific Reports 2016;6:29418
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