QS 11 (CAS 944328-88-5): R&D Systems
Catalog Number: 3324
Chemical Name: (2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
Biological Activity
GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
Technical Data
  • M.Wt:
    567.68
  • Formula:
    C36H33N5O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    944328-88-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule synergist of the Wnt/β-catenin signaling pathway.
    Zhang et al.
    Proc.Natl.Acad.Sci.USA, 2007;104:7444
  2. A chemical approach to stem cell biology
    Emre et al.
    Curr.Opin.Chem.Biol., 2007;11:252
Citations:

The citations listed below are publications that use Tocris products. Selected citations for QS 11 include:

1 Citations: Showing 1 - 1

  1. Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles
    Authors: Wu, J Et al.
    Scientific Reports 2016;6:29418?

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