Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Biological ActivityAtypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Seroquel: biochemical profile of a potential atypical antipsychotic.
Saller and Salama
Psychopharmacology (Berl.), 1993;112:285
Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz.
Ellenbroek et al.
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