Catalog Number: 4735
Alternate Names: ICI 204,636
Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Biological Activity
Atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
Technical Data
  • M.Wt:
    441.54
  • Formula:
    C21H25N3O2S.0.5C4H4O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    111974-72-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Seroquel: biochemical profile of a potential atypical antipsychotic.
    Saller and Salama
    Psychopharmacology (Berl.), 1993;112:285
  2. Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with clozapine.
    Ellenbroek et al.
    Neuropsychopharmacology, 1996;15:406

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