Quetiapine hemifumarate

Key Product Details

Product Description

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT₂) and dopamine (D₂) receptors (IC₅₀ values are 148 and 329 nM respectively). Lacks affinity at either D₁ or muscarinic receptors.

Product Specifications for Quetiapine hemifumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Quetiapine hemifumarate

The following data is based on the product molecular weight 441.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.53 mL	22.65 mL	45.30 mL
2.5 mM	0.91 mL	4.53 mL	9.06 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ellenbroek Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 1996 PMID: 8887995
• Saller and Salama Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 1993 PMID: 7871032

Product Documents for Quetiapine hemifumarate