Catalog Number: 5583
Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Biological Activity
Potent and selective FPR2 agonist (EC50 = 40 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.
Technical Data
  • M.Wt:
    445.51
  • Formula:
    C26H27N3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    786706-21-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1.
    Zhou et al.
    Mol.Pharmacol., 2007;72:976
  2. FPR2/ALXR agonists and the resolution of inflammation.
    Corminboeuf et al.
    J.Med.Chem., 2014;58:537
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Quin C1 include:

1 Citations: Showing 1 - 1

  1. Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone.
    Authors: Ma Et al.
    Int J Neuropsychopharmacol 2015;18

Have you used Quin C1?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information