Catalog Number: 5583
Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Biological Activity
Potent and selective FPR2 agonist (EC50 = 40 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1.
    Zhou et al.
    Mol.Pharmacol., 2007;72:976
  2. FPR2/ALXR agonists and the resolution of inflammation.
    Corminboeuf et al.
    J.Med.Chem., 2014;58:537

The citations listed below are publications that use Tocris products. Selected citations for Quin C1 include:

Showing Results 1 - 1 of 1

  1. Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone.
    Authors: Ma Et al.
    Int J Neuropsychopharmacol
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