Chemical Name: 4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Biological ActivityQuin C1 is a potent and selective FPR2 agonist (EC50 = 15 nM). Induces Ca2+ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1.
Zhou et al.
FPR2/ALXR agonists and the resolution of inflammation.
Corminboeuf et al.
Citation for Quin C1
The citations listed below are publications that use Tocris products. Selected citations for Quin C1 include:
1 Citation: Showing 1 - 1
Agonist and antagonist effects of aripipr. on D2-like receptors controlling rat brain DA synthesis depend on the DArgic tone.
Authors: Ma Et al.
Int J Neuropsychopharmacol 2015;18
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