Catalog Number: 0629
Chemical Name: 2-(1-Piperazinyl)quinoline dimaleate
Biological Activity
Selective 5-HT3 receptor agonist. Also displays antagonist activity at peripheral 5-HT3 receptors. [3H]-Quipazine labels 5-HT3 sites in the cortical membranes.
Technical Data
  • M.Wt:
    445.43
  • Formula:
    C13H15N3.2C4H4O4
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    150323-78-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characteristics of 5-HT3 binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [3H]-quipazine and [3H]-GR65630 binding.
    Sharif et al.
    Br.J.Pharmacol., 1991;102:919
  2. [3H]Quipazine labels 5-HT3 recognition sites in rat cortical membranes.
    Peroutka and Hamik
    Eur.J.Pharmacol., 1988;148:297
  3. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve.
    Ireland and Tyers
    Br.J.Pharmacol., 1987;90:229
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Quipazine dimaleate include:

1 Citations: Showing 1 - 1

  1. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Br J Pharmacol 2012;37:321

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