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R 1485 dihydrochloride

4964 Datasheet / COA / SDS

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4964 has been discontinued.
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R 1485 dihydrochloride | 5-HT6 Receptor Antagonists
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Description: Selective and high affinity 5-HT6 antagonist

Chemical Name: 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride

Purity: ≥98%

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Biological Activity

R 1485 dihydrochloride is a selective and high affinity 5-HT6 antagonist (pKi = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.

Technical Data

M.Wt:
450.35
Formula:
C18H20FN3O3S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 5-HT6 antagonists as potential treatment for cognitive dysfunction.
    Liu et al.
    Drug Des.Rev., 2009;70:145
  2. 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.
    Zhao et al.
    Bioorg.Med.Chem.Lett., 2007;17:3504

Product Datasheets

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