R 1485 dihydrochloride

Key Product Details

Product Description

R 1485 dihydrochloride is a selective and high affinity 5-HT₆ antagonist (pK_i = 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.

Product Specifications for R 1485 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for R 1485 dihydrochloride

The following data is based on the product molecular weight 450.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.20 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liu 5-HT₆ antagonists as potential treatment for cognitive dysfunction. Drug Des.Rev.
• Zhao 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT₆ receptor antagonists. Bioorg.Med.Chem.Lett. 2007 PMID: 17485206

Product Documents for R 1485 dihydrochloride