Selective and high affinity 5-HT6
= 8.9); displays low hERG inhibition. Exhibits >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Brain penetrant.
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All Tocris products are intended for laboratory research use only.
3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.
Zhao et al.
5-HT6 antagonists as potential treatment for cognitive dysfunction.
Liu et al.
Drug Des.Rev., 2009;70:145