Alternate Names:D-α-hydroxyglutaric acid disodium salt
Chemical Name:(R)-2-Hydroxypentanedioic acid disodium salt
Biological Activity Oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells.
Soluble to 100 mM in water
Store at -20°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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