(R)-2-Hydroxyglutaric acid disodium salt

Key Product Details

Product Description

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N⁶-methyladenine demethylase).

Product Specifications for (R)-2-Hydroxyglutaric acid disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (R)-2-Hydroxyglutaric acid disodium salt

The following data is based on the product molecular weight 192.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.21 mL	26.03 mL	52.06 mL
5 mM	1.04 mL	5.21 mL	10.41 mL
10 mM	0.52 mL	2.60 mL	5.21 mL
50 mM	0.10 mL	0.52 mL	1.04 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Carbonneau The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 2016 PMID: 27624942
• Mauer FTO controls reversible m⁶Am RNA methylation during snRNA biogenesis. Nat.Chem.Biol. 2019 PMID: 30778204
• Chen The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 2016 PMID: 27577048

Product Documents for (R)-2-Hydroxyglutaric acid disodium salt