(R)-2-Hydroxyglutaric acid disodium salt

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(R)-2-Hydroxyglutaric acid disodium salt | CAS No. 103404-90-6 | NFkB/IkB Activators
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Description: KDM4A inhibitor; also NF-κB activator
Alternative Names: D-α-hydroxyglutaric acid disodium salt

Chemical Name: (R)-2-Hydroxypentanedioic acid disodium salt

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Biological Activity

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).

Technical Data

M.Wt:
192.08
Formula:
C5H6Na2O5
Solubility:
Soluble to 100 mM in water
Storage:
Store at -20°C
CAS No:
103404-90-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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