Catalog Number: 6124
Alternate Names: D-α-hydroxyglutaric acid disodium salt
Chemical Name: (R)-2-Hydroxypentanedioic acid disodium salt
Biological Activity
Oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells.
Technical Data
  • M.Wt:
    192.08
  • Formula:
    C5H6Na2O5
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at -20°C
  • CAS No:
    103404-90-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.
    Chen et al.
    Sci.Rep., 2016;6:32428
  2. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.
    Carbonneau et al.
    Nat.Commun., 2016;7:12700
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