Catalog Number: 3815
Chemical Name: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride
Biological Activity
Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.
Technical Data
  • M.Wt:
    340.29
  • Formula:
    C18H22ClNO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    177172-49-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency.
    Wada et al.
    J.Clin.Invest., 1997;100:2977
  2. NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium.
    Fox et al.
    J.Pharmacol.Exp.Ther., 1999;290:473
  3. Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor.
    Ying Lin Lu et al.
    J.Pharmacol.Exp.Ther., 2009;331:775
Citations:

The citations listed below are publications that use Tocris products. Selected citations for R 568 hydrochloride include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    EMBO Mol Med 2015;7:284ra60
  2. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension.
    Authors: Yamamura Et al.
    Sci Transl Med 2015;10:e0138384
  3. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
    Authors: Engelstoft Et al.
    Mol Metab 2013;2:376
  4. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
  5. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Authors: Yamamura Et al.
    Circ Res 2012;111:469

Have you used R 568 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information