R 568 hydrochloride

  ( 7 citations )    
Product Datasheet
Catalog Number:3815
Chemical Name:2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride
Product Details
Citations (7)
Supplemental Products
Reviews
Biological Activity
Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.
Technical Data
  • M.Wt:
    340.29
  • Formula:
    C18H22ClNO.HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    177172-49-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for R 568 hydrochloride include:

7 Citations: Showing 1 - 7
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  1. Cinacalcet inhibits neuroblastoma tumor growth and upregulates cancer-testis antigens.
    Authors: Rodríguez-Hernández Et al.
    Oncotarget  2016;7:16112
  2. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    EMBO Mol Med  2015;7:284ra60
  3. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension.
    Authors: Yamamura Et al.
    Sci Transl Med  2015;10:e0138384
  4. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
    Authors: Engelstoft Et al.
    Mol Metab  2013;2:376
  5. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  6. Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.
    Authors: Cheng
    Am J Physiol Gastrointest Liver Physiol  2012;303:G60
  7. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.
    Authors: Yamamura Et al.
    Circ Res  2012;111:469

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