R 568 hydrochloride

Catalog # Availability Size / Price Qty
R 568 hydrochloride | CAS No. 177172-49-5 | Calcium-Sensing Receptor Modulators
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Description: Positive allosteric modulator of human calcium-sensing receptor (CaSR)

Chemical Name: 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride

Purity: ≥99%

Product Details
Citations (11)
Supplemental Products

Biological Activity

R 568 hydrochloride is a positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for R 568 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for R 568 hydrochloride include:

11 Citations: Showing 1 - 10

  1. Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine.
    Authors: Zhang Et al.
    Front Physiol  2019;9:1922
  2. Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion.
    Authors: Tang Et al.
    Sci Rep  2018;8:7851
  3. Calcimimetic R568 reduced the blood pressure and improved aortic remodeling in spontaneously hypertensive rats by inhibiting local renin-angiotensin system activity.
    Authors: Sun Et al.
    Exp Ther Med  2018;16:4089
  4. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation.
    Authors: Zhang Et al.
    Cell Physiol Biochem  2017;43:1777
  5. Cinacalcet inhibits neuroblastoma tumor growth and upregulates cancer-testis antigens.
    Authors: Rodríguez-Hernández Et al.
    Oncotarget  2016;7:16112
  6. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Authors: Yarova Et al.
    EMBO Mol Med  2015;7:284ra60
  7. Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension.
    Authors: Yamamura Et al.
    Sci Transl Med  2015;10:e0138384
  8. Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells.
    Authors: Engelstoft Et al.
    Mol Metab  2013;2:376
  9. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature  2012;492:123
  10. Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.
    Authors: Cheng
    Am J Physiol Gastrointest Liver Physiol  2012;303:G60


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