Catalog Number: 5432
Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Biological Activity
Inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
Technical Data
  • M.Wt:
    380.77
  • Formula:
    C16H8ClF3N4S
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    303997-35-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice.
    King et al.
    Neurosci.Lett., 2013;542:92
  2. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1.
    Gururaja et al.
    Chem.Biol., 2007;14:1105

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