Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Biological ActivityR 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1.
Gururaja et al.
TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice.
King et al.
Citation for R 7050
The citations listed below are publications that use Tocris products. Selected citations for R 7050 include:
1 Citation: Showing 1 - 1
Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.
Authors: Gonzalez-Juarbe Et al.
Cell Death Differ 2017;24:917
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for R 7050
There are currently no reviews for this product. Be the first to review R 7050 and earn rewards!
Have you used R 7050?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image