R 7050

Tocris Bioscience | Catalog # 5432

Inhibitor of TNF-α receptor 1 signaling
Tocris Bioscience

Key Product Details

Description

Inhibitor of TNF-α receptor 1 signaling
View all Additional Cytokine Receptor Products »

Product Description

R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.

Product Specifications for R 7050

Molecular Weight

380.77

Formula

C16H8ClF3N4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline

CAS Number

303997-35-5

PubChem ID

1486608

InChI Key

SUUMKHOVGVYGOP-UHFFFAOYSA-N

SMILES

ClC1=CC=C(N=C(SC4=CC=CC=C4)C2=NN=C(C(F)(F)F)N23)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.62 20

Preparing Stock Solutions for R 7050

The following data is based on the product molecular weight 380.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 13.13 mL 65.66 mL 131.31 mL
1 mM 2.63 mL 13.13 mL 26.26 mL
2 mM 1.31 mL 6.57 mL 13.13 mL
10 mM 0.26 mL 1.31 mL 2.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

Product Documents for R 7050

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for R 7050

For research use only

Customer Reviews for R 7050 (1)

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  • R 7050 inhibits 15d-PGJ2 induced caspase activation
    Name: Chintan Koyani
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: HL-1 cardiomyocytes
    Verified Customer | Posted 10/13/2018
    HL-1 cells were incubated with R 7050 (30 μM) for 30 min prior to 15d-PGJ2 (15 μM) treatments for 4 h to follow markers of apoptosis. Pharmacological antagonism of TNF receptor inhibited 15d-PGJ2-induced caspase 3/8/9 activation (shown in Image).
    R 7050 5432

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