Inhibitor of TNF-α
receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α
B and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.
Soluble to 20 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice.
King et al.
A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1.
Gururaja et al.