R 715

  ( 6 citations )    
Product Datasheet
Catalog Number:3407
Chemical Name:
Product Details
Citations (6)
Supplemental Products
Reviews
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
Technical Data
  • M.Wt:
    1140.35
  • Formula:
    C57H81N13O12
  • Sequence:
    KRPPGFSXI

    (Modifications: Lys-1 = N-terminal Ac, X = DβNal)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    185052-09-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for R 715 include:

6 Citations: Showing 1 - 6
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  1. Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.
    Authors: Brailoiu
    Neuroscience  2017;365:23
  2. A role for bradykinin signaling in chronic vulvar pain.
    Authors: Falsetta Et al.
    The Journal of Pain  2016;
  3. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
    Authors: Kawaguchi Et al.
    J Cereb Blood Flow Metab  2015;9:229
  4. Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.
    Authors: Xu Et al.
    Am J Respir Cell Mol Biol  2014;51:370
  5. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal  2013;11:70
  6. Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
    Authors: Albert-Weissenberger Et al.
    EMBO Mol Med  2012;32:1747

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