Catalog Number: 3407
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
Technical Data
  • M.Wt:
    1140.35
  • Formula:
    C57H81N13O12
  • Sequence:
    KRPPGFSXI

    (Modifications: Lys-1 = N-terminal Ac, X = DβNal)

  • Solubility:
    Soluble to 5 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    185052-09-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors.
    Quintao et al.
    J.Neurosci., 2008;28:2856
  2. Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors.
    Abdouh et al.
    Br.J.Pharmacol., 2008;154:136
  3. Structure-activity studies of B1 receptor-related peptides.
    Gobeil et al.
    Hypertension., 1996;28:833
Citations:

The citations listed below are publications that use Tocris products. Selected citations for R 715 include:

4 Citations: Showing 1 - 4
Filter your results:

  1. A role for bradykinin signaling in chronic vulvar pain.
    Authors: Falsetta Et al.
    The Journal of Pain 2016;
  2. Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
    Authors: Kawaguchi Et al.
    J Cereb Blood Flow Metab 2015;9:229
  3. Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
    Authors: Pinheiro Et al.
    Cell Commun Signal 2013;11:70
  4. Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
    Authors: Albert-Weissenberger Et al.
    EMBO Mol Med 2012;32:1747

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