Biological ActivityR 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
(Modifications: Lys-1 = N-terminal Ac, X = DβNal)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure-activity studies of B1 receptor-related peptides.
Gobeil et al.
Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors.
Quintao et al.
Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors.
Abdouh et al.
Citations for R 715
The citations listed below are publications that use Tocris products. Selected citations for R 715 include:
6 Citations: Showing 1 - 6
Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.
A role for bradykinin signaling in chronic vulvar pain.
Authors: Falsetta Et al.
The Journal of Pain 2016;
Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons.
Authors: Kawaguchi Et al.
J Cereb Blood Flow Metab 2015;9:229
Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4.
Authors: Xu Et al.
Am J Respir Cell Mol Biol 2014;51:370
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Authors: Pinheiro Et al.
Cell Commun Signal 2013;11:70
Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.
Authors: Albert-Weissenberger Et al.
EMBO Mol Med 2012;32:1747
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