R 892

Catalog # Availability Size / Price Qty
3226/1
R 892
1 Image
Description: Potent and selective B1 antagonist
Product Details
Citations (1)
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Biological Activity

Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Technical Data

M.Wt:
1154.37
Formula:
C58H83N13O12
Sequence:
KRPPGFSXI

(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
229030-05-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity studies of B1 receptor related peptide.
    Gobeil et al.
    Hypertension, 1996;28:833
  2. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.
    Duka et al.
    Hypertension, 2003;42:1021
  3. Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities.
    Gobeil et al.
    Hypertension, 1998;33:823

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Citation for R 892

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