Catalog Number: 3226
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-activity studies of B1 receptor related peptide.
    Gobeil et al.
    Hypertension, 1996;28:833
  2. Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.
    Duka et al.
    Hypertension, 2003;42:1021
  3. Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities.
    Gobeil et al.
    Hypertension, 1998;33:823

The citations listed below are publications that use Tocris products. Selected citations for R 892 include:

1 Citations: Showing 1 - 1

  1. Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
    Authors: Mattis Et al.
    J Neurosci 2014;34:11769

Have you used R 892?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details


Contact Information


Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 


Customer Information