R 892

Name: R 892
Brand: Tocris Bioscience
SKU: 3226

Tocris Bioscience | Catalog # 3226

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Citations (23)

Product Documents

Potent and selective B1 antagonist

Discontinued Product

3226 has been discontinued. View all Bradykinin Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective B1 antagonist

View all Bradykinin Receptor Antagonists »

Product Description

R 892 is a potent and selective bradykinin B₁ receptor antagonist (ID₅₀ values are 2.8 and > 600 nM at B₁ and B₂ receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.

Product Specifications for R 892

Molecular Weight

1154.37

Formula

C₅₈H₈₃N₁₃O₁₂

Storage

Desiccate at -20°C

CAS Number

229030-05-1

PubChem ID

10374059

InChI Key

STDZHNYUPODPLD-DDLDLQAOSA-N

SMILES

CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@](C)(CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Mass

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Concentration 1 (C1)

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Concentration 2 (C2)

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 23 publications citing the usage of this product.

Duka Mechanisms mediating the vasoactive effects of the B₁ receptors of bradykinin. Hypertension 2003 PMID: 14557281
Gobeil Kinin B₁ receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities. Hypertension
Gobeil Structure-activity studies of B₁ receptor related peptide. Hypertension 1996 PMID: 8901831

Product Documents for R 892

Certificate of Analysis

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Product Specific Notices for R 892

For research use only

Citations for R 892

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