R 892
Biological Activity
Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive activity in vivo.Technical Data
(Modifications: Lys-1 = N-terminal Ac, Phe-6 = (αMe)Phe, X = DβNal)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structure-activity studies of B1 receptor related peptide.
Gobeil et al.
Hypertension, 1996;28:833 -
Mechanisms mediating the vasoactive effects of the B1 receptors of bradykinin.
Duka et al.
Hypertension, 2003;42:1021 -
Kinin B1 receptor antagonists containing α-methyl-L-phenylalanine: in vitro and in vivo antagonistic activities.
Gobeil et al.
Hypertension, 1998;33:823
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Citation for R 892
The citations listed below are publications that use Tocris products. Selected citations for R 892 include:
1 Citation: Showing 1 - 1
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Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
Authors: Mattis Et al.
J Neurosci 2014;34:11769
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