(R)-(-)-α-Methylhistamine dihydrobromide

Tocris Bioscience | Catalog # 0569

Potent, standard H3 agonist
Tocris Bioscience

Key Product Details

Description

Potent, standard H3 agonist
View all Histamine H3 Receptor Agonists »

Product Description

(R)-(-)-α-Methylhistamine dihydrobromide is a very potent, high affinity H3 agonist (KD = 50.3 nM) that displays > 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM).

S-enantiomer also available.

Product Specifications for (R)-(-)-α-Methylhistamine dihydrobromide

Molecular Weight

287.00

Formula

C6H11N3.2HBr

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide

CAS Number

868698-49-1

PubChem ID

45037031

InChI Key

RWHNAAABSGVRDT-ZJIMSODOSA-N

SMILES

N[C@H](C)CC1=CNC=N1.Br.Br

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 28.7 100

Preparing Stock Solutions for (R)-(-)-α-Methylhistamine dihydrobromide

The following data is based on the product molecular weight 287.00.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.42 mL 34.84 mL
5 mM 0.70 mL 3.48 mL 6.97 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for (R)-(-)-α-Methylhistamine dihydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-(-)-α-Methylhistamine dihydrobromide

For research use only

Citations for (R)-(-)-α-Methylhistamine dihydrobromide

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