(R)-(-)-Phenylephrine hydrochloride

Catalog # Availability Size / Price Qty
(R)-(-)-Phenylephrine hydrochloride | CAS No. 61-76-7 | Adrenergic alpha-1 Receptor Agonists
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Description: α1 agonist

Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products

Biological Activity

(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Scientific Data

Binding Activity phenylephrine affects cardiomyocyte contraction rates View Larger

Small molecules affect cardiomyocyte contraction rates. The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for (R)-(-)-Phenylephrine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:

4 Citations: Showing 1 - 4


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