(R)-(-)-Phenylephrine hydrochloride

Tocris Bioscience | Catalog # 2838

α1 agonist
Tocris Bioscience

Key Product Details

Description

α1 agonist
View all Adrenergic alpha-1 Receptor Agonists »

Product Description

(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Scientific Data Images for (R)-(-)-Phenylephrine hydrochloride

phenylephrine affects cardiomyocyte contraction rates

Small molecules affect cardiomyocyte contraction rates.

The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

Product Specifications for (R)-(-)-Phenylephrine hydrochloride

Molecular Weight

203.67

Formula

C9H13NO2.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

(R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride

CAS Number

61-76-7

PubChem ID

441279

InChI Key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

SMILES

OC1=CC=CC([C@@H](O)CNC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.37 100
DMSO 20.37 100

Preparing Stock Solutions for (R)-(-)-Phenylephrine hydrochloride

The following data is based on the product molecular weight 203.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.91 mL 24.55 mL 49.10 mL
5 mM 0.98 mL 4.91 mL 9.82 mL
10 mM 0.49 mL 2.45 mL 4.91 mL
50 mM 0.10 mL 0.49 mL 0.98 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for (R)-(-)-Phenylephrine hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (R)-(-)-Phenylephrine hydrochloride

For research use only

Citations for (R)-(-)-Phenylephrine hydrochloride

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  • Adrenergic agonist
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 10/02/2018
    Elicits calcium increase in astrocytes at 100uM

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